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Acknowledgements This work was partially funded by the Italian Ministry of Education (MIUR, Grant to GS) and by Sigma Tau Industrie Farmaceutiche Riunite (Grant to GR)

Oral NAD+ supplements must pass through the digestive system, where absorption is significantly limited (often less than 15%)

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Long-term effects: Long-term safety of retatrutide at high doses outside of controlled trials is not fully researched

However, due to discrepancies in findings from clinical trials, real-world data, and fundamental research, definitive recommendations for diabetic retinopathy screening prior to GLP-1 RA treatment initiation remain elusive